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Performing Single-Cell Analyses

Recent evidence suggests that long non-coding RNAs (lncRNAs) play important roles in shaping the dynamic 3D organization of the genome.

We are developing novel tools that enable comprehensive measurements of these dynamic higher-order RNA-DNA interactions in single cells. These tools will enable key advances towards understanding how 3D nuclear organization is achieved and how its disruption can impact gene regulation and ultimately lead to human disease.