Positions

Scientific Director

We are seeking a Scientific Director to assist with the execution of the ambitious research agenda of the laboratory.  The position will support the PI, students and postdoctoral researchers in the laboratory in execution of research via five avenues; personnel assistance, laboratory/facilities, research funding, research support, and training in the area of molecular biology/microbiology. Please see the full Caltech HR job posting for more information and details on how to apply.




Microbiology and antibiotic resistance Post-docs

We are seeking talented, motivated individuals to join a collaborative effort to discover new microbiology to enable development of rapid diagnostic tests of antibiotic susceptibility. The work combines fundamental microbiological studies of the mechanisms by which microbes respond to short-term antibiotic exposure and creative applications of knowledge gained to create new technologies.

Rapid, point-of-care (POC) antibiotic susceptibility testing (AST) is critically needed so clinicians can provide timely and correct treatment and minimize further spread of “superbugs.” Our lab has demonstrated (doi: 10.1126/scitranslmed.aal3693) that we can use digital, single-molecule counting methods to perform a rapid phenotypic AST directly on clinical UTI samples with sample-to-answer results in less than 30 min.

Skills required: Strong microbiological training; creativity; rigorous scientific training in design and interpretation of experiments; knowledge of the mechanism of action of antibiotics; knowledge of prokaryotic gene regulation preferred; strong experimental skills with RG2 pathogens and/or clinical samples preferred; familiarity with current antimicrobial susceptibility testing methodology preferred; expertise working with BSL-2 organismspreferred.¬† Priority will be given to candidates who have demonstrated a published record of creativity, scientific depth, and research accomplishments. Candidates are encouraged to identify and apply for postdoctoral fellowships and other independent funding sources for which they are eligible.¬†Candidates should send their CV and a brief statement of research interests to ismagilov.postdoc@caltech.edu.

Single-Cell Molecular Biology Post-Doc
Applications are invited for a Postdoctoral position in the Ismagilov group at the California Institute of Technology.  Appointees will work on an NIH funded collaborative project between the Ismagilov and Guttman labs to study the 3-dimensional structure of nuclei in single cells across time using a combination of microfluidic technologies and molecular biology techniques. The appointee will develop methods to comprehensively map DNA-DNA, DNA-RNA, and RNA-RNA interactions within the nucleus, as well as help implement those methods in microfluidic devices for the study of single cells. Required skills include: molecular biology and biochemistry and familiarity with sequencing and bioinformatics. Applicants must have demonstrated a published record of  creativity, depth, and accomplishment.  Experience with single cell methodologies and associated challenges is considered a plus. Candidates should send to ismagilov.postdoc@caltech.edu a CV and a brief statement of research interests.

Single-Cell Microfluidics Post-Doc
Applications are invited for a Postdoctoral position in the Ismagilov group at the California Institute of Technology.  Appointees will work on an NIH funded collaborative project between the Ismagilov and Guttman labs to study the 3-dimensional structure of nuclei in single cells across time using a combination of microfluidic technologies and molecular biology techniques. The appointee will develop and refine microfluidic devices for performing multi-step biochemical protocols on individual cells and nuclei in order to comprehensively map DNA-DNA, DNA-RNA, and RNA-RNA interactions within the nucleus. Required skills include: strong background in fundamentals of microfluidics, with experience in biochemistry and molecular and cell biology in microfluidic devices.  Applicants must have demonstrated a published record of  creativity, depth, and accomplishment.  Experience with single cell methodologies and associated challenges is considered a plus. Candidates should send to ismagilov.postdoc@caltech.edu a CV and a brief statement of research interests.

Microbe-Host Interactions Post-Doc
We are seeking a postdoc in microbiology to work in our lab, in close collaboration with the lab of Dr. Sarkis K. Mazmanian. The goal of our project is to understand the role of spatial structure in microbe-microbe and host-microbe interactions, and to use this understanding to control these interactions. More information on this position is available here. We welcome postdoctoral applications from talented, motivated individuals. Our postdocs typically come from diverse backgrounds including chemistry, physics, biology, biochemistry, microbiology, chemical and biological engineering. Candidates should send to ismagilov.postdoc@caltech.edu a CV and a brief statement of research interests.



GRADUATE APPLICANTS

Prospective graduate students who are interested in joining the lab need to apply for one of the degree options described on the Caltech Graduate Studies Office website. Applicants can find more information on degree options, including Chemical & Chemical Engineering, Bioengineering, Biophysics, Biology & Microbiology, Materials Science, and Applied Physics, here.

CALTECH GRAD-STUDENT ROTATIONS

We welcome inquiries from incoming Caltech graduate students interested in joining or doing rotations in the lab. Please contact rustem.admin@caltech.edu.

CALTECH UNDERGRADS

Current Caltech undergraduate students interested in doing research in the lab should send a resume and a very brief statement of research interests to rustem.admin@caltech.edu.





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